How the ubiquitin-proteasome system controls transcription

Nat Rev Mol Cell Biol. 2003 Mar;4(3):192-201. doi: 10.1038/nrm1049.


Gene transcription and ubiquitin-mediated proteolysis are two processes that have seemingly nothing in common: transcription is the first step in the life of any protein and proteolysis the last. Despite the disparate nature of these processes, a growing body of evidence indicates that ubiquitin and the proteasome are intimately involved in gene control. Here, we discuss the deep mechanistic connections between transcription and the ubiquitin-proteasome system, and highlight how the intersection of these processes tightly controls expression of the genetic information.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chromatin / metabolism
  • DNA-Directed RNA Polymerases / metabolism
  • Endopeptidases / genetics
  • Endopeptidases / metabolism*
  • Humans
  • Models, Biological
  • Transcription, Genetic*
  • Ubiquitin / metabolism
  • Ubiquitins / genetics
  • Ubiquitins / metabolism*


  • Chromatin
  • Ubiquitin
  • Ubiquitins
  • DNA-Directed RNA Polymerases
  • Endopeptidases