The role of Tec family kinases in T cell development and function

Immunol Rev. 2003 Feb;191:119-38. doi: 10.1034/j.1600-065x.2003.00029.x.

Abstract

Three members of the Tec family kinases, Itk, Rlk and Tec, have been implicated in signaling downstream of the T cell receptor (TCR). The activity of these kinases in T cells has been shown to be important for the full activation of phospholipase C-gamma1 (PLC-gamma1). Disruption of Tec family signaling in Itk-/- and Rlk-/-Itk-/- mice has multiple effects on T cell development, cytokine production and T-helper cell differentiation. Furthermore, mice possessing mutations in signaling molecules upstream of PLC-gamma1, such as Src homology 2 (SH2) domain-containing phosphoprotein of 76 kDa (SLP-76), linker for activation of T cells (LAT) and Vav1, or in members of the nuclear factor for activated T cells (NFAT) family of transcription factors, which are downstream of PLC-gamma1, have been found to have similar phenotypes to Tec family-deficient mice, emphasizing the importance of this pathway in regulating T cell activation, differentiation and homeostasis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / physiology*
  • CD8-Positive T-Lymphocytes / physiology*
  • Calcium Signaling / physiology
  • DNA-Binding Proteins / metabolism
  • Humans
  • Mice
  • NFATC Transcription Factors
  • Nuclear Proteins*
  • Phospholipase C gamma
  • Protein-Tyrosine Kinases / physiology*
  • Signal Transduction / physiology
  • Transcription Factors / metabolism
  • Type C Phospholipases / metabolism

Substances

  • DNA-Binding Proteins
  • NFATC Transcription Factors
  • Nuclear Proteins
  • Transcription Factors
  • Tec protein-tyrosine kinase
  • Protein-Tyrosine Kinases
  • Type C Phospholipases
  • Phospholipase C gamma