Type 1 diabetes islet autoantibody markers

Diabetes Technol Ther. 2002;4(6):817-39. doi: 10.1089/152091502321118838.


The diagnosis of type 1 diabetes versus other forms of diabetes such as type 2 diabetes is paramount to guiding proper therapy. Several islet autoantibodies have been identified that serve to diagnose immune-mediated, type 1a diabetes in clinically ambiguous cases. These autoantibodies also serve to predict type 1 diabetes in nondiabetic individuals. The most useful islet autoantibodies include islet cell cytoplasmic autoantibodies, insulin autoantibodies, glutamic acid decarboxylase autoantibodies, and insulinoma-associated-2 autoantibodies. Once type 1 diabetes can be safely and reliably prevented, large-scale islet autoantibody screening programs of the general pediatric population may be warranted. It is controversial whether islet autoantibodies influence the course of type 1 diabetes following diagnosis.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoantibodies / analysis*
  • Biomarkers / analysis
  • Diabetes Mellitus, Type 1 / diagnosis
  • Diabetes Mellitus, Type 1 / immunology*
  • Glutamate Decarboxylase / immunology
  • Humans
  • Insulin / immunology
  • Islets of Langerhans / immunology


  • Autoantibodies
  • Biomarkers
  • ICA512 autoantibody
  • Insulin
  • islet cell antibody
  • Glutamate Decarboxylase