Evidence for sexual difference in astrocytes of adult rat hippocampus

Neurosci Lett. 2003 Mar 20;339(2):119-22. doi: 10.1016/s0304-3940(02)01484-2.


We quantified the number of glial fibrillary acidic protein immunoreactive (GFAP-IR) astrocytes in the CA1 and CA3 areas of the adult rat hippocampus. The dorsal and ventral regions of the hippocampus were taken into account to estimate the GFAP-IR cells using unbiased stereological techniques. Males had a higher number of GFAP-IR astrocytes in the CA3 area, whereas females had more in the CA1 area. No sex difference was found between dorsal and ventral regions, although most GFAP-IR astrocytes were located in the dorsal hippocampus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Astrocytes / cytology*
  • Astrocytes / metabolism
  • Female
  • Glial Fibrillary Acidic Protein / metabolism
  • Hippocampus / cytology*
  • Hippocampus / metabolism
  • Immunohistochemistry
  • Male
  • Rats
  • Rats, Wistar
  • Sex Factors


  • Glial Fibrillary Acidic Protein