P. aeruginosa quorum-sensing systems and virulence

Curr Opin Microbiol. 2003 Feb;6(1):56-60. doi: 10.1016/s1369-5274(03)00008-0.


Quorum sensing is an important mechanism for the regulation of genes in many Gram-negative and Gram-positive bacteria. In the opportunistic pathogen Pseudomonas aeruginosa, the absence of one or more components of the quorum-sensing system results in a significant reduction in virulence. Recent advances in the past year have demonstrated that the quorum-sensing signal molecule 3O-C(12)-HSL is also a potent stimulator of multiple eukaryotic cells and thus may alter the host response during P. aeruginosa infections. Therefore, via the regulation of multiple factors and the production of 3O-C(12)-HSL, quorum-sensing systems have a significant effect on the virulence of the bacteria and also on how the host responds to P. aeruginosa infections.

Publication types

  • Review

MeSH terms

  • 4-Butyrolactone / analogs & derivatives*
  • 4-Butyrolactone / metabolism
  • Gene Expression Regulation, Bacterial
  • Humans
  • Interleukins / classification
  • Interleukins / metabolism
  • Models, Biological
  • Pseudomonas aeruginosa / genetics
  • Pseudomonas aeruginosa / pathogenicity*
  • Signal Transduction
  • Virulence / genetics


  • Interleukins
  • homoserine lactone
  • 4-Butyrolactone