The in vitro susceptibility of Scedosporium prolificans to ajoene, allitridium and a raw extract of garlic (Allium sativum)

J Antimicrob Chemother. 2003 Mar;51(3):593-7. doi: 10.1093/jac/dkg144.

Abstract

The in vitro susceptibility of 20 medical isolates of Scedosporium prolificans to ajoene, allitridium and raw garlic extract derived from cloves of garlic (Allium sativum) was tested using the NCCLS reference method (with minor modifications) for broth microdilution. The results demonstrate that both garlic derivatives and raw garlic extract appear to have in vitro activity against S. prolificans.

MeSH terms

  • Allyl Compounds / pharmacology*
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology*
  • Disulfides / pharmacology*
  • Garlic*
  • Humans
  • Microbial Sensitivity Tests / statistics & numerical data
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Structures
  • Scedosporium / drug effects*
  • Scedosporium / isolation & purification
  • Sulfides / pharmacology*
  • Sulfoxides

Substances

  • Allyl Compounds
  • Antifungal Agents
  • Disulfides
  • Plant Extracts
  • Sulfides
  • Sulfoxides
  • diallyl trisulfide
  • ajoene