Substituted quinolines induce inhibition of proliferation of HTLV-1 infected cells

Alain Fournet; Renaud Mahieux; Mohammed A Fakhfakh; Xavier Franck; Reynald Hocquemiller; Bruno Figadère

doi:10.1016/s0960-894x(02)01085-5

Substituted quinolines induce inhibition of proliferation of HTLV-1 infected cells

Bioorg Med Chem Lett. 2003 Mar 10;13(5):891-4. doi: 10.1016/s0960-894x(02)01085-5.

Authors

Alain Fournet¹, Renaud Mahieux, Mohammed A Fakhfakh, Xavier Franck, Reynald Hocquemiller, Bruno Figadère

Affiliation

¹ Laboratoire de Pharmacognosie (associé au CNRS-BioCIS) Faculté de Pharmacie, Université de Paris-Sud, rue J. B. Clément, 92296 Châtenay-Malabry, France.

PMID: 12617915
DOI: 10.1016/s0960-894x(02)01085-5

Abstract

Several quinolines were synthesized and evaluated against HTLV-1 infected cells. Some of them were able to inhibit HTLV-1 cell-growth at 10 microM. Some structure-activity relationships were observed.

MeSH terms

Cell Division / drug effects
Cell Line
Cell Transformation, Viral
HTLV-I Infections / drug therapy*
Human T-lymphotropic virus 1 / drug effects*
Human T-lymphotropic virus 1 / growth & development
Humans
Quinolines / chemistry*
Quinolines / pharmacology*
Structure-Activity Relationship
T-Lymphocytes / cytology
T-Lymphocytes / microbiology

Substances

Quinolines