BAG-1: a multifunctional regulator of cell growth and survival

Biochim Biophys Acta. 2003 Mar 17;1603(2):83-98. doi: 10.1016/s0304-419x(03)00002-7.


BAG-1 is multifunctional protein which interacts with a wide range of cellular targets to regulate growth control pathways important for normal and malignant cells, including apoptosis, signaling, proliferation, transcription and cell motility. Of particular relevance to tumour cells, BAG-1 interacts with the anti-apoptotic BCL-2 protein, various nuclear hormone receptors and the 70 kDa heat shock proteins, Hsc70 and Hsp70. Interaction with chaperones may account for many of the pleiotropic effects associated with BAG-1 overexpression. Recent studies have shown that BAG-1 expression is frequently altered in malignant cells, and BAG-1 expression may have clinical value as a prognostic/predictive marker. This review summarises current understanding of molecular mechanisms of BAG-1 expression and function.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis / physiology*
  • Carrier Proteins / biosynthesis
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Cell Division
  • Cell Survival
  • DNA-Binding Proteins
  • Gene Expression Regulation
  • HSC70 Heat-Shock Proteins
  • HSP70 Heat-Shock Proteins / metabolism
  • Humans
  • Molecular Sequence Data
  • Plants
  • Protein Isoforms / physiology
  • Sequence Alignment
  • Signal Transduction
  • Transcription Factors
  • Transcription, Genetic


  • BCL2-associated athanogene 1 protein
  • Carrier Proteins
  • DNA-Binding Proteins
  • HSC70 Heat-Shock Proteins
  • HSP70 Heat-Shock Proteins
  • HSPA8 protein, human
  • Protein Isoforms
  • Transcription Factors