Effect of medium-chain triglycerides on the postprandial triglyceride concentration in healthy men

Biosci Biotechnol Biochem. 2003 Jan;67(1):46-53. doi: 10.1271/bbb.67.46.


This study compared the serum lipid concentrations after a single dose of medium-chain triglycerides (MCT) or long-chain triglycerides (LCT) between individuals grouped according to the body mass index (BMI). Twenty-five males participated as volunteers, the test diet containing 10 g of MCT or LCT. Blood samples were collected up to 6 h after the intake of a test diets. The LCT diet resulted in significantly greater increases in areas under the curves (AUCs) for serum and chylomicron triglyceride in the BMI > or = 23 kg/m2 group than those in the BMI < 23 kg/m2 group. The magnitude of response after intake of the MCT diet by the BMI > or = 23 kg/m2 group was significantly lower than that after the LCT diet. These results suggest that, in subjects with BMI > or = 23 kg/m2, the intake of MCT is preferable to that of LCT for maintaining postprandial triglyceride at a low concentration.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Animals
  • Blood Chemical Analysis
  • Body Mass Index
  • Cholesterol / blood
  • Cross-Over Studies
  • Diet
  • Dietary Fats, Unsaturated / pharmacology
  • Double-Blind Method
  • Humans
  • Lipids / blood
  • Lipoproteins / blood
  • Male
  • Postprandial Period / physiology*
  • Rats
  • Triglycerides / metabolism*
  • Triglycerides / pharmacology*


  • Dietary Fats, Unsaturated
  • Lipids
  • Lipoproteins
  • Triglycerides
  • Cholesterol