Effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility to Listeria infection

Biosci Biotechnol Biochem. 2003 Jan;67(1):89-93. doi: 10.1271/bbb.67.89.

Abstract

We studied the effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the susceptibility to Listeria infection of offspring in C57BL /6NCji mice. The offspring were nursed by TCDD-treated dams and exposed to TCDD from birth to weaning via milk. The exposure had little effect on the weights of immune organs and the spleen or the thymus cell population in the dams and offspring, but it enhanced the production of tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) in the serum after Listeria infection. The clearance of Listeria monocytogenes from the spleen was impaired in the off-spring. These results suggest that the exposure to TCDD of the offspring via milk disrupted the host resistance of the offspring, even though the main immune parameters were unchanged.

MeSH terms

  • Animals
  • Cytokines / metabolism
  • Environmental Pollutants / toxicity*
  • Female
  • Flow Cytometry
  • Interferon-gamma / biosynthesis
  • Interferon-gamma / genetics
  • Lactation / physiology*
  • Listeria monocytogenes
  • Listeriosis / immunology*
  • Listeriosis / microbiology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Milk / chemistry
  • Polychlorinated Dibenzodioxins / toxicity*
  • Pregnancy
  • Sex Characteristics
  • Spleen / drug effects
  • Spleen / immunology
  • Thymus Gland / drug effects
  • Thymus Gland / immunology
  • Tumor Necrosis Factor-alpha / biosynthesis
  • Tumor Necrosis Factor-alpha / genetics

Substances

  • Cytokines
  • Environmental Pollutants
  • Polychlorinated Dibenzodioxins
  • Tumor Necrosis Factor-alpha
  • Interferon-gamma