Is topical nifedipine effective for chronic anal fissures?

J Fam Pract. 2003 Mar;52(3):190-2.

Abstract

Patients in this study showed remarkable improvement when 1.5% lidocaine and 0.3% nifedipine were applied twice daily for 6 weeks. This extremely safe, well tolerated, and effective treatment should provide family physicians with a reliable nonsurgical method for treating chronic anal fissures.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Topical
  • Anesthetics, Local / therapeutic use
  • Chronic Disease
  • Double-Blind Method
  • Evidence-Based Medicine
  • Fissure in Ano / drug therapy*
  • Fissure in Ano / prevention & control
  • Humans
  • Lidocaine / therapeutic use
  • Nifedipine / therapeutic use*
  • Ointments
  • Pain Measurement
  • Practice Guidelines as Topic
  • Randomized Controlled Trials as Topic
  • Secondary Prevention
  • Treatment Outcome
  • Vasodilator Agents / therapeutic use*
  • Wound Healing / drug effects

Substances

  • Anesthetics, Local
  • Ointments
  • Vasodilator Agents
  • Lidocaine
  • Nifedipine