Abstract
CD4 and CD8 genes are integral indicators of T-cell lineage commitment. New insights into the control of expression of these genes have come from recent reports implicating chromatin-remodelling factors in their regulation.
MeSH terms
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Animals
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CD4 Antigens / genetics
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CD4 Antigens / physiology*
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CD8 Antigens / genetics
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CD8 Antigens / physiology*
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Cell Differentiation / physiology*
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Chromatin / physiology*
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Core Binding Factor Alpha 2 Subunit
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Core Binding Factor Alpha 3 Subunit
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Gene Expression Regulation / physiology
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Mice
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Neoplasm Proteins*
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Proto-Oncogene Proteins*
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T-Lymphocytes / physiology*
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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CD4 Antigens
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CD8 Antigens
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Chromatin
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Core Binding Factor Alpha 2 Subunit
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Core Binding Factor Alpha 3 Subunit
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DNA-Binding Proteins
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Neoplasm Proteins
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Proto-Oncogene Proteins
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Runx3 protein, mouse
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Transcription Factors