T-cell differentiation: chromatin remodelling in CD4/CD8 regulation

Curr Biol. 2003 Mar 4;13(5):R189-91. doi: 10.1016/s0960-9822(03)00121-0.

Abstract

CD4 and CD8 genes are integral indicators of T-cell lineage commitment. New insights into the control of expression of these genes have come from recent reports implicating chromatin-remodelling factors in their regulation.

MeSH terms

  • Animals
  • CD4 Antigens / genetics
  • CD4 Antigens / physiology*
  • CD8 Antigens / genetics
  • CD8 Antigens / physiology*
  • Cell Differentiation / physiology*
  • Chromatin / physiology*
  • Core Binding Factor Alpha 2 Subunit
  • Core Binding Factor Alpha 3 Subunit
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation / physiology
  • Mice
  • Neoplasm Proteins*
  • Proto-Oncogene Proteins*
  • T-Lymphocytes / physiology*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • CD4 Antigens
  • CD8 Antigens
  • Chromatin
  • Core Binding Factor Alpha 2 Subunit
  • Core Binding Factor Alpha 3 Subunit
  • DNA-Binding Proteins
  • Neoplasm Proteins
  • Proto-Oncogene Proteins
  • Runx3 protein, mouse
  • Transcription Factors