Enforced proximity in the function of a famous scaffold

Mol Cell. 2003 Feb;11(2):289-91. doi: 10.1016/s1097-2765(03)00055-8.

Abstract

Recent studies by Park, Zarrinipar, and Lim with reengineered Ste5 scaffold proteins underscore the fundamental importance of proximity in enzyme regulation and of keeping a proper distance for maintaining signaling specificity.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Genes, Fungal
  • Models, Biological
  • Mutation
  • Protein Engineering
  • Saccharomyces cerevisiae / chemistry
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / physiology*
  • Signal Transduction

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • STE5 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins