A clinical series of 62 patients who underwent cranioplasty using a new quick-setting hydroxyapatite (HA) material was done over a 2-year period. The majority of procedures (69%) were performed for secondary reconstruction of frontal, temporal, and supraorbital deficiencies after primary repair of a craniosynostosis. The frontal sinus was obliterated as part of the cranioplastic procedure in 5 cases (8%) in older patients. The material set effectively in approximately 5 minutes with a good working time. Infection occurred in 3 patients (5%) which was treated by removing the HA cranioplastic material. This faster-setting HA material offers similar cranioplastic benefits as other materials but with an accelerated intraoperative set time.