HLA typing does not predict REM sleep behaviour disorder and hallucinations in Parkinson's disease

Mov Disord. 2003 Mar;18(3):337-340. doi: 10.1002/mds.10409.

Abstract

HLA-DR2 haplotype and DQ1 DNA alleles, characterizing 90 to 100% of all narcoleptic patients, were found to be equally distributed in 20 Parkinson's disease (PD) patients with early hallucinations, rapid eye movement (REM) sleep-related behaviour disturbances (RBD), and sleep onset in REM (SOREM), and in 20 PD patients without hallucinations, despite 10 to 15 years of treatment, and no RBD or SOREM.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Carrier Proteins / genetics
  • Female
  • HLA-DR2 Antigen / genetics
  • Hallucinations / diagnosis
  • Hallucinations / genetics*
  • Haplotypes
  • Histocompatibility Testing
  • Humans
  • Male
  • Molecular Chaperones*
  • Parkinson Disease / genetics*
  • REM Sleep Behavior Disorder / diagnosis
  • REM Sleep Behavior Disorder / genetics*
  • Sampling Studies

Substances

  • Carrier Proteins
  • HLA-DR2 Antigen
  • Molecular Chaperones
  • TOR1A protein, human
  • TOR1B protein, human