Comparison of neonatal effects of epidural and general anesthesia for cesarean section

Gynecol Obstet Invest. 2003;55(1):41-5. doi: 10.1159/000068956.

Abstract

We assessed the influence of anesthetic technique for cesarean section on neonatal outcome. Thirty parturient women (ASA I/II) were randomly allocated into two groups. In Group GA general anesthesia was induced with 4 mg.kg(-1) thiopental and 1.5 mg.kg(-1) succinylcholine. In group EA epidural anesthesia was performed with 20 ml 0.375% bupivacaine through L(3-4) inter-space. 1-min Apgar scores were significantly higher in group EA (p < 0.001). Neurologic and Adaptive Capacity scores at 2 and 24 h were higher in group EA (p < 0.001). In terms of blood gas values, umbilical arterial pH and pO(2) values were higher in group EA (p < 0.05 and p < 0.001, respectively). The first breast-feeding intervals were found to be shorter in group EA (p < 0.001). We conclude that in terms of better Apgar and NAC scores, acid-base status and earlier initiation of breast-feeding, the epidural anesthesia may be preferred to general anesthesia in cesarean section.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anesthesia, Epidural / adverse effects
  • Anesthesia, Epidural / methods*
  • Anesthesia, General / adverse effects
  • Anesthesia, General / methods*
  • Anesthesia, Obstetrical / adverse effects
  • Anesthesia, Obstetrical / methods*
  • Anesthetics, Inhalation / administration & dosage
  • Anesthetics, Inhalation / pharmacology
  • Anesthetics, Local / administration & dosage
  • Anesthetics, Local / pharmacology
  • Apgar Score
  • Bupivacaine / administration & dosage
  • Bupivacaine / pharmacology
  • Cesarean Section / methods*
  • Female
  • Humans
  • Infant, Newborn / physiology*
  • Isoflurane / administration & dosage
  • Isoflurane / pharmacology
  • Nitrous Oxide / administration & dosage
  • Nitrous Oxide / pharmacology
  • Pregnancy
  • Succinylcholine / administration & dosage
  • Thiopental / administration & dosage

Substances

  • Anesthetics, Inhalation
  • Anesthetics, Local
  • Isoflurane
  • Succinylcholine
  • Thiopental
  • Nitrous Oxide
  • Bupivacaine