Distribution, blood transport, and degradation of antidiuretic hormone in man

J Clin Invest. 1976 May;57(5):1109-16. doi: 10.1172/JCI108377.

Abstract

The distribution, blood transport, and metabolic clearance of physiological concentrations of antidiuretic hormone were studied in 10 hydrated normal subjects with radioiodinated arginine vasopressin (125I-AVP). At 37 degrees C no binding of 125I-AVP to plasma proteins could be demonstrated, but some metabolites were associated with plasma proteins. 125I-AVP was rapidly distributed into a space approximating the extracellular fluid volume. Metabolic breakdown products became demonstrable within minutes after injection. The mean metabolic clearance rate of 125I-AVP was 4.1 ml/min/kg and the mean plasma half-life 24.1 min. Renal clearance had a mean value of 80 ml/min and accounted for 27% of the total metabolic clearance. It is concluded that in man antidiuretic hormone circulates as a free (non-protein bound) peptide, diffuses readily into the extracellular fluid space, and is metabolized within minutes. A plasma half-life of 24 min is consistent with the duration of antidiuresis after hormone administration or release.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Arginine Vasopressin / blood
  • Arginine Vasopressin / metabolism*
  • Arginine Vasopressin / urine
  • Chromatography, Paper
  • Female
  • Humans
  • Iodoproteins
  • Male
  • Vasopressins / analogs & derivatives*

Substances

  • Iodoproteins
  • Vasopressins
  • Arginine Vasopressin