Abstract
The in vitro anti-influenza virus effects of some isoquinoline alkaloids, isolated from Thalictrum species (Ranunculaceae), growing in Mongolia and Sweden have been studied. (-)-thalimonine (Thl) and (-)-thalimonine N-oxide, isolated from the Mongolian plant T. simplex, inhibited markedly the influenza virus reproduction in vitro; thalictuberine N-oxide was less effective. The synthetic analogues of Thl as well as the rest of the tested alkaloids, isolated from T. foetidum and T. flavum, were not active. At a concentration range between 0.1 - 6.4 microM Thl inhibited viral reproduction in a selective and specific way.
MeSH terms
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Alkaloids / administration & dosage
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Alkaloids / pharmacology
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Alkaloids / therapeutic use
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Antiviral Agents / administration & dosage
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Antiviral Agents / pharmacology*
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Antiviral Agents / therapeutic use
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Dose-Response Relationship, Drug
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Humans
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Influenza, Human / drug therapy
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Inhibitory Concentration 50
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Isoquinolines / administration & dosage
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Isoquinolines / pharmacology
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Isoquinolines / therapeutic use
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Orthomyxoviridae / drug effects*
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Thalictrum*
Substances
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Alkaloids
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Antiviral Agents
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Isoquinolines
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Plant Extracts