Hypothyroidism as a cause of rhabdomyolysis

Endocr J. 2002 Dec;49(6):621-3. doi: 10.1507/endocrj.49.621.


We describe a patient presenting with muscular symptoms and rhabdomyolysis without any other precipitating factor, except primary hypothyroidism. After thyroxine replacement, musculoskeletal symptoms disappeared and creatine kinase concentrations decreased. Hypothyroidism is a rare cause of rhabdomyolysis, but should always be considered in a patient with an unexplained increase in creatine kinase concentrations.

MeSH terms

  • Creatine Kinase / blood
  • Hormone Replacement Therapy
  • Humans
  • Hypothyroidism / blood
  • Hypothyroidism / complications*
  • Hypothyroidism / drug therapy
  • Male
  • Middle Aged
  • Rhabdomyolysis / blood
  • Rhabdomyolysis / drug therapy
  • Rhabdomyolysis / etiology*
  • Thyroxine / therapeutic use


  • Creatine Kinase
  • Thyroxine