GUGULIPID: a natural cholesterol-lowering agent

Annu Rev Nutr. 2003;23:303-13. doi: 10.1146/annurev.nutr.23.011702.073102. Epub 2003 Feb 26.

Abstract

The resin of the Commiphora mukul tree has been used in Ayurvedic medicine for more than 2000 years to treat a variety of ailments. Studies in both animal models and humans have shown that this resin, termed gum guggul, can decrease elevated lipid levels. The stereoisomers E- and Z-guggulsterone have been identified as the active agents in this resin. Recent studies have shown that these compounds are antagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which is an important regulator of cholesterol homeostasis. It is likely that this effect accounts for the hypolipidemic activity of these phytosteroids.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cholesterol / metabolism*
  • Cholesterol, Dietary / administration & dosage
  • Commiphora
  • DNA-Binding Proteins / metabolism
  • Disease Models, Animal
  • Humans
  • Hyperlipidemias / drug therapy*
  • Hypolipidemic Agents / adverse effects
  • Hypolipidemic Agents / pharmacology*
  • Hypolipidemic Agents / therapeutic use
  • Plant Extracts / adverse effects
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Gums
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors / metabolism

Substances

  • Cholesterol, Dietary
  • DNA-Binding Proteins
  • Hypolipidemic Agents
  • Plant Extracts
  • Plant Gums
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • farnesoid X-activated receptor
  • guggulu extract
  • Cholesterol