Molecular approaches to spinal cord repair

Annu Rev Neurosci. 2003;26:411-40. doi: 10.1146/annurev.neuro.26.043002.094946. Epub 2003 Feb 26.

Abstract

Axon growth inhibitors associated with myelin and the glial scar contribute to the failure of axon regeneration in the injured adult mammalian central nervous system (CNS). A number of these inhibitors, their receptors, and signaling pathways have been identified. These inhibitors can now be neutralized by a variety of approaches that point to the possibility of developing new therapeutic strategies to stimulate regeneration after spinal cord injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / physiology
  • Cicatrix / metabolism
  • Humans
  • In Vitro Techniques
  • Molecular Biology*
  • Myelin Proteins / metabolism
  • Myelin Sheath / physiology
  • Myelin-Associated Glycoprotein / metabolism
  • Nerve Regeneration / physiology*
  • Neural Inhibition
  • Nogo Proteins
  • Signal Transduction / physiology
  • Spinal Cord Injuries* / genetics
  • Spinal Cord Injuries* / physiopathology
  • Spinal Cord Injuries* / therapy

Substances

  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Nogo Proteins
  • RTN4 protein, human