Molecular approaches to spinal cord repair

Annu Rev Neurosci. 2003;26:411-40. doi: 10.1146/annurev.neuro.26.043002.094946. Epub 2003 Feb 26.


Axon growth inhibitors associated with myelin and the glial scar contribute to the failure of axon regeneration in the injured adult mammalian central nervous system (CNS). A number of these inhibitors, their receptors, and signaling pathways have been identified. These inhibitors can now be neutralized by a variety of approaches that point to the possibility of developing new therapeutic strategies to stimulate regeneration after spinal cord injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / physiology
  • Cicatrix / metabolism
  • Humans
  • In Vitro Techniques
  • Molecular Biology*
  • Myelin Proteins / metabolism
  • Myelin Sheath / physiology
  • Myelin-Associated Glycoprotein / metabolism
  • Nerve Regeneration / physiology*
  • Neural Inhibition
  • Nogo Proteins
  • Signal Transduction / physiology
  • Spinal Cord Injuries* / genetics
  • Spinal Cord Injuries* / physiopathology
  • Spinal Cord Injuries* / therapy


  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Nogo Proteins
  • RTN4 protein, human