SET-ting the stage for life and death

Cell. 2003 Mar 7;112(5):589-91. doi: 10.1016/s0092-8674(03)00151-x.

Abstract

Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Chromosomal Proteins, Non-Histone / genetics
  • Chromosomal Proteins, Non-Histone / metabolism*
  • DNA-Binding Proteins
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism*
  • Granzymes
  • HMGB2 Protein / metabolism
  • Histone Chaperones
  • Humans
  • Monomeric GTP-Binding Proteins / genetics
  • Monomeric GTP-Binding Proteins / metabolism*
  • NM23 Nucleoside Diphosphate Kinases
  • Nuclear Proteins / metabolism
  • Nucleoside-Diphosphate Kinase*
  • Phosphoproteins / metabolism
  • Serine Endopeptidases / genetics
  • Serine Endopeptidases / metabolism*
  • Signal Transduction / physiology*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • HMGB2 Protein
  • Histone Chaperones
  • NM23 Nucleoside Diphosphate Kinases
  • Nuclear Proteins
  • Phosphoproteins
  • SET protein, human
  • Transcription Factors
  • NME1 protein, human
  • Nucleoside-Diphosphate Kinase
  • Granzymes
  • Serine Endopeptidases
  • GZMA protein, human
  • Monomeric GTP-Binding Proteins