Dopamine Modulation of Perisomatic and Peridendritic Inhibition in Prefrontal Cortex

J Neurosci. 2003 Mar 1;23(5):1622-30. doi: 10.1523/JNEUROSCI.23-05-01622.2003.

Abstract

The computations underlying cognitive functions are performed by a diversity of interactions between interneurons and pyramidal neurons that are subject to modulatory influences. Here we have used paired whole-cell recording to study the influence of dopamine on local inhibitory circuits involving fast-spiking (FS) and non-FS cells, respectively. We found that dopamine depressed inhibitory transmission between FS interneurons and pyramidal neurons but enhanced inhibition between non-FS interneurons and pyramidal cells. FS inhibitory transmission exhibited properties associated with presynaptic action at D(1) receptors that were not evident in non-FS inhibitory connections. In addition, FS and non-FS interneurons differed morphologically, forming contacts on the perisomatic and peridendritic domains, respectively, of their pyramidal cell targets. These findings provide evidence for both a dual mode of inhibition in prefrontal circuitry and circuit-dependent modulation by dopamine.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology
  • Animals
  • Dendrites / physiology
  • Dopamine / pharmacology
  • Dopamine / physiology*
  • Dopamine Agonists / pharmacology
  • Dopamine Antagonists / pharmacology
  • Dose-Response Relationship, Drug
  • Electric Stimulation / methods
  • Ferrets
  • In Vitro Techniques
  • Interneurons / drug effects
  • Interneurons / physiology
  • Nerve Net / drug effects
  • Nerve Net / physiology
  • Neural Inhibition / drug effects
  • Neural Inhibition / physiology*
  • Neurons / drug effects
  • Neurons / physiology*
  • Patch-Clamp Techniques
  • Prefrontal Cortex / cytology
  • Prefrontal Cortex / drug effects
  • Prefrontal Cortex / physiology*
  • Pyramidal Cells / drug effects
  • Pyramidal Cells / physiology
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology*
  • gamma-Aminobutyric Acid / pharmacology

Substances

  • Dopamine Agonists
  • Dopamine Antagonists
  • gamma-Aminobutyric Acid
  • Dopamine