Enantioselective cyanosilylation of ketones by a catalytic double-activation method employing chiral Lewis acid and achiral N-oxide catalysts

Fuxue Chen; Xiaoming Feng; Bo Qin; Guolin Zhang; Yaozhong Jiang

doi:10.1021/ol034158a

Enantioselective cyanosilylation of ketones by a catalytic double-activation method employing chiral Lewis acid and achiral N-oxide catalysts

Org Lett. 2003 Mar 20;5(6):949-52. doi: 10.1021/ol034158a.

Authors

Fuxue Chen¹, Xiaoming Feng, Bo Qin, Guolin Zhang, Yaozhong Jiang

Affiliation

¹ Sichuan Key Laboratory of Green Chemistry and Technology, College of Chemistry, Sichuan University, Chengdu 610064, China.

PMID: 12633113
DOI: 10.1021/ol034158a

Abstract

[reaction: see text] Enantioselective addition of TMSCN to ketones is achieved by a catalytic double-activation method using 1a-Ti(IV) complex as the Lewis acid and achiral N-oxide 2 as the Lewis base to activate ketones and TMSCN, respectively.