T-cell responses of vaccinated cancer patients

Curr Opin Immunol. 2003 Apr;15(2):131-7. doi: 10.1016/s0952-7915(03)00009-8.


Following vaccination with defined tumor antigens that are recognized by T cells, a small proportion of cancer patients display tumor regressions. Several reports describe anti-vaccine T-cell responses, evaluated with a variety of methods, for example, by assessing T-cell function or expression of specific TCR. However, a correlation between these T-cell responses and the tumor regressions has not yet been established. It appears that some patients display tumor regression with an unexpectedly low frequency of anti-vaccine T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigens, Neoplasm / immunology
  • Cancer Vaccines / genetics
  • Cancer Vaccines / therapeutic use*
  • Dendritic Cells / immunology
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Melanoma / drug therapy
  • Melanoma / genetics
  • Melanoma / immunology
  • Monitoring, Immunologic / methods
  • Neoplasm Proteins / immunology
  • Receptors, Antigen, T-Cell / genetics
  • T-Lymphocytes / drug effects*
  • T-Lymphocytes / immunology
  • Vaccination


  • Antigens, Neoplasm
  • Cancer Vaccines
  • MAGEA3 protein, human
  • Neoplasm Proteins
  • Receptors, Antigen, T-Cell