An eight-cysteine-containing CFEM domain unique to a group of fungal membrane proteins

Trends Biochem Sci. 2003 Mar;28(3):118-21. doi: 10.1016/S0968-0004(03)00025-2.


CFEM, an eight cysteine-containing domain, has been identified by analyzing over 25 fungal sequences selected from database sequence searches. Features of CFEM suggest that it is a novel domain with characteristics distinct from known cysteine-rich domains. Some CFEM-containing proteins (e.g. Pth11 from Magnaporthe grisea) are proposed to have important roles in fungal pathogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Cysteine / chemistry*
  • Cysteine / genetics
  • Fungal Proteins / chemistry*
  • Fungal Proteins / genetics
  • Membrane Proteins / chemistry*
  • Membrane Proteins / genetics
  • Molecular Sequence Data
  • Plant Proteins / chemistry
  • Plant Proteins / genetics
  • Plant Proteins / metabolism
  • Protein Structure, Tertiary*
  • Sequence Alignment


  • Fungal Proteins
  • Membrane Proteins
  • Plant Proteins
  • Cysteine

Associated data

  • GENBANK/AY166602