Associations of weight loss and changes in fat distribution with the remission of hypertension in a bi-ethnic cohort: the Atherosclerosis Risk in Communities Study

Prev Med. 2003 Mar;36(3):330-9. doi: 10.1016/s0091-7435(02)00063-4.

Abstract

Background: To examine associations of weight loss and changes in fat distribution with changes in blood pressure and the remission of hypertension in a community-based sample.

Methods: Participants were 3245 white and African-American men and women, 45-64 years of age, who participated in the Atherosclerosis Risk in Communities Study over an average of 9 years. Mixed models analyses were used to examine the associations of weight loss and changes in fat distribution with changes in blood pressure. Proportional hazard models with time-dependent covariates were used to examine the associations of weight loss and changes in fat distribution with the remission of hypertension.

Results: Weight loss was associated with a decrease in systolic blood pressure and diastolic blood pressure and with an increased rate of remission of hypertension. Hazard ratios of the remission of hypertension associated with 1-kg increment in annual weight loss were 2.04 (95% confidence interval [CI]: 1.62-2.59), 1.38 (95% CI: 1.14-1.67), 1.84 (95% CI: 1.47-2.29), and 1.53 (95% CI: 1.14-2.05) for white women, African-American women, white men, and African-American men, respectively. Changes in fat distribution were associated with the remission of hypertension in younger (45-54 years) participants.

Conclusions: Weight loss was associated with a decrease in blood pressure and with remission of hypertension in white and African-American men and women.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • African Americans / statistics & numerical data*
  • Age Distribution
  • Arteriosclerosis / epidemiology*
  • Arteriosclerosis / prevention & control
  • Body Composition*
  • Body Mass Index
  • Cohort Studies
  • Comorbidity
  • Confidence Intervals
  • Female
  • Humans
  • Hypertension / epidemiology*
  • Hypertension / prevention & control
  • Incidence
  • Male
  • Middle Aged
  • Obesity / ethnology*
  • Obesity / prevention & control*
  • Primary Prevention / organization & administration*
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Factors
  • Sex Distribution
  • United States / epidemiology
  • Weight Loss*
  • Whites / statistics & numerical data*