From words to literature in structural proteomics

Nature. 2003 Mar 13;422(6928):216-25. doi: 10.1038/nature01513.


Technical advances on several frontiers have expanded the applicability of existing methods in structural biology and helped close the resolution gaps between them. As a result, we are now poised to integrate structural information gathered at multiple levels of the biological hierarchy - from atoms to cells - into a common framework. The goal is a comprehensive description of the multitude of interactions between molecular entities, which in turn is a prerequisite for the discovery of general structural principles that underlie all cellular processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Crystallization
  • Humans
  • Microscopy, Electron / methods
  • Models, Molecular
  • Protein Conformation
  • Proteome / chemistry*
  • Proteome / metabolism*
  • Proteomics / methods*
  • Proteomics / trends*


  • Proteome