Disease proteomics

Nature. 2003 Mar 13;422(6928):226-32. doi: 10.1038/nature01514.


The sequencing of the human genome and that of numerous pathogens has opened the door for proteomics by providing a sequence-based framework for mining proteomes. As a result, there is intense interest in applying proteomics to foster a better understanding of disease processes, develop new biomarkers for diagnosis and early detection of disease, and accelerate drug development. This interest creates numerous opportunities as well as challenges to meet the needs for high sensitivity and high throughput required for disease-related investigations.

Publication types

  • Review

MeSH terms

  • Disease*
  • Drug Design
  • Electrophoresis, Gel, Two-Dimensional
  • Gene Expression Profiling* / methods
  • Humans
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Oligonucleotide Array Sequence Analysis
  • Protein Array Analysis
  • Proteome / genetics
  • Proteome / metabolism
  • Proteomics / methods*


  • Proteome