Primary gastric T-cell lymphoma not associated with human T-lymphotropic virus type I: a case report and review of the literature

Ann Hematol. 2003 Mar;82(3):197-202. doi: 10.1007/s00277-003-0612-6. Epub 2003 Feb 13.


Primary gastric T-cell lymphoma (PGTL) not associated with human T-lymphotropic virus type I (HTLV-I) is extremely rare and such a case is reported herein. The patient was a 58-year-old Japanese male presenting with submucosal tumor of the stomach identified on endoscopic examination. The lesion was diagnosed as non-Hodgkin's lymphoma by endoscopic biopsy and classified as peripheral T-cell lymphoma, unspecified, due to clonal rearrangement of the T-cell receptor beta (TCR) gene and expression of TCR beta protein in the absence of B-cell genotypes and phenotypes. Unlike previously reported cases of HTLV-I-unassociated PGTL, lymphoma in the current case was characterized histologically as "low grade" and phenotypically as CD4+, TIA-1+, granzyme B+, and CD103-. The lymphoma responded well to chemotherapy and radiation, and the patient was well with no detectable disease 10 months after initiation of therapy. A review of patients with PGTL in the literature revealed a few long-term survivors, and the investigation of therapeutic strategies for PGTL is, therefore, necessary.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biopsy
  • Blotting, Southern
  • Bone Marrow / pathology
  • Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
  • Humans
  • Immunophenotyping
  • Lymphoma, T-Cell / genetics
  • Lymphoma, T-Cell / pathology*
  • Lymphoma, T-Cell / therapy
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Radiotherapy
  • Receptors, Antigen, T-Cell, alpha-beta / genetics
  • Stomach Neoplasms / genetics
  • Stomach Neoplasms / pathology*
  • Stomach Neoplasms / therapy


  • Receptors, Antigen, T-Cell, alpha-beta