Anisotropic properties of tracheal smooth muscle tissue

J Biomed Mater Res A. 2003 Apr 1;65(1):1-8. doi: 10.1002/jbm.a.10355.


The anisotropic (directional-dependent) properties of contracting tracheal smooth muscle tissue are estimated from a computational model based on the experimental data of length-dependent stiffness. The area changes are obtained at different muscle lengths from experiments in which stimulated muscle undergoes unrestricted shortening. Then, through an interative process, the anisotropic properties are estimated by matching the area changes obtained from the finite element analysis to those derived from the experiments. The results obtained indicate that the anisotropy ratio (longitudinal stiffness to transverse stiffness) is about 4 when the smooth muscle undergoes 70% strain shortening, indicating that the transverse stiffness reduces as the longitudinal stiffness increases. It was found through a sensitivity analysis from the simulation model that the longitudinal stiffness and the in-plane shear modulus are not very sensitive as compared to major Poisson's ratio to the area changes of the muscle tissue.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms
  • Animals
  • Anisotropy
  • Biomechanical Phenomena
  • Compliance
  • Computer Simulation
  • Dogs
  • Finite Element Analysis
  • In Vitro Techniques
  • Muscle Contraction / physiology
  • Muscle, Smooth / physiology*
  • Poisson Distribution
  • Trachea / physiology*
  • Transducers