Specialization of Tumour Vasculature

Nat Rev Cancer. 2002 Feb;2(2):83-90. doi: 10.1038/nrc724.

Abstract

Tumour blood vessels express markers that are not present in resting blood vessels of normal tissues, but that can be shared by angiogenic vessels in non-malignant conditions. Many of these proteins are functionally important in the angiogenic process. Some tumours also contain lymphatic vessels, as well as channels that consist of cancer cells and their extracellular matrix. These special features of tumour vessels are good targets for cancer therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / analysis
  • Humans
  • Integrins / metabolism
  • Lymphatic System / pathology*
  • Neoplasms / blood supply*
  • Neoplasms / immunology
  • Neovascularization, Pathologic / pathology*
  • Peptide Library
  • Receptors, Vascular Endothelial Growth Factor / metabolism

Substances

  • Biomarkers, Tumor
  • Integrins
  • Peptide Library
  • Receptors, Vascular Endothelial Growth Factor