Second cancers in survivors of childhood cancer

Nat Rev Cancer. 2002 Feb;2(2):124-32. doi: 10.1038/nrc722.


More than 70% of children diagnosed with cancer can now be expected to be long-term survivors. However, the consequences of 'cure' might be considerable for the survivors of cancer: 60-70% of young adults who have survived childhood cancer will develop at least one medical disability as a result of their cancer or, more commonly, as a result of their therapy. Of these, the most devastating is a second cancer.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Drug-Related Side Effects and Adverse Reactions
  • Environment
  • Humans
  • Neoplasms / drug therapy
  • Neoplasms / epidemiology*
  • Neoplasms / mortality
  • Neoplasms / radiotherapy
  • Neoplasms, Second Primary / epidemiology*
  • Neoplasms, Second Primary / etiology*
  • Radiotherapy / adverse effects
  • Risk Factors
  • Survival
  • Time Factors