Error theory and ageing in human diploid fibroblasts

Nature. 1972 Oct 6;239(5371):316-8. doi: 10.1038/239316a0.

Abstract

Immunological and enzymatic assessments of lactate dehydrogenase in human lung fibroblasts strongly suggest that altered proteins accumulate in ageing cells. This supports but does not prove the error catastrophe theory of all death.

MeSH terms

  • Amino Acids / metabolism
  • Animals
  • Cell Count
  • Cell Death
  • Cellular Senescence / physiology*
  • Deoxyribonucleases / metabolism
  • Diploidy*
  • Ethionine / metabolism
  • Fibroblasts / cytology*
  • Fibroblasts / drug effects
  • Fibroblasts / enzymology*
  • Fibroblasts / metabolism
  • Fluorouracil / pharmacology
  • Humans
  • L-Lactate Dehydrogenase / genetics
  • L-Lactate Dehydrogenase / metabolism*
  • Lung
  • Methionine / metabolism
  • Models, Biological*
  • Protein Biosynthesis*
  • Ribonucleases / metabolism

Substances

  • Amino Acids
  • Methionine
  • L-Lactate Dehydrogenase
  • Deoxyribonucleases
  • Ribonucleases
  • Fluorouracil
  • Ethionine