Pro-fibrogenic effects of magnesium deficiency in the cardiovascular system

Magnes Res. 2002 Dec;15(3-4):307-15.


Magnesium deficiency is known to produce cardiovascular injury. A large body of experimental evidence supports the postulation that an immuno-inflammatory reaction and increased oxidative stress may damage the myocardium and vasculature in magnesium deficiency. Reparative/reactive fibrosis in response to the injury has, however, received little attention. Recent evidence from a rodent model of acute magnesium deficiency suggests that humoral factors may activate cardiac fibroblasts by a free radical-mediated mechanism and contribute to cardiac fibrogenesis. A similar mechanism may also promote cellular hyperplasia and increased matrix synthesis in the vasculature.

Publication types

  • Review

MeSH terms

  • Cardiomyopathies / pathology
  • Cardiovascular Diseases / pathology
  • Cardiovascular System / metabolism*
  • Fibrinogen / biosynthesis*
  • Humans
  • Magnesium Deficiency / metabolism*
  • Magnesium Deficiency / pathology


  • Fibrinogen