Helicobacter pylori infection: CagA-specific antibodies are associated with clinical outcome, but not with HLA-class II polymorphisms of the host

Int J Med Microbiol. 2003 Feb;292(7-8):537-40. doi: 10.1078/1438-4221-00237.

Abstract

In order to investigate the interrelation between immunogenetic host and bacterial factors the T-cell receptor (TCR) polymorphism TCRBV6S1 A/B, HLA-DRB1 alleles and cagA status was analyzed in 380 unrelated German individuals. H. pylori infection with cagA-positive bacterial strains was significantly associated with peptic ulcer disease in the German cohort. Patients homozygous for the non-functional TCRBV6S1B allele and presenting with peptic ulcer disease showed no CagA-specific antibodies in the majority of cases. There was no association between HLA-DRB1 alleles and the CagA status of infected individuals, although certain alleles show significant association to the infection status in different populations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Antibodies, Bacterial / blood*
  • Antigens, Bacterial*
  • Bacterial Proteins / immunology*
  • Genetic Predisposition to Disease
  • Germany
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Helicobacter Infections / immunology
  • Helicobacter Infections / microbiology
  • Helicobacter Infections / physiopathology
  • Helicobacter pylori / immunology*
  • Humans
  • Peptic Ulcer / immunology
  • Peptic Ulcer / microbiology
  • Peptic Ulcer / physiopathology
  • Polymorphism, Genetic*

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Proteins
  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • cagA protein, Helicobacter pylori