Selenium deficiency in a patient with Crohn's disease receiving long-term total parenteral nutrition

Intern Med. 2003 Feb;42(2):154-7. doi: 10.2169/internalmedicine.42.154.

Abstract

We report a case of selenium deficiency in a patient with Crohn's disease on long-term total parenteral nutrition (TPN). She manifested lassitude of the legs, discoloration of the nail beds, and macrocytosis. Since her plasma selenium level was found to be below the measurable level, we diagnosed this case as selenium deficiency. After intravenous administration of sodium selenite, her symptoms were reversed. Careful attention should be paid to selenium deficiency when a patient receives long-term TPN; supplementary administration of selenium via TPN may be required because selenium is often not routinely added to TPN formulations.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Colectomy / adverse effects
  • Colectomy / methods
  • Crohn Disease / diagnosis*
  • Crohn Disease / surgery
  • Deficiency Diseases / diagnosis*
  • Deficiency Diseases / drug therapy
  • Deficiency Diseases / etiology
  • Dietary Supplements
  • Female
  • Follow-Up Studies
  • Humans
  • Long-Term Care
  • Parenteral Nutrition / adverse effects*
  • Parenteral Nutrition / methods
  • Reoperation
  • Risk Assessment
  • Selenium / deficiency*
  • Severity of Illness Index
  • Short Bowel Syndrome / etiology
  • Short Bowel Syndrome / therapy*
  • Sodium Selenite / therapeutic use*
  • Treatment Outcome

Substances

  • Selenium
  • Sodium Selenite