Neurologic complications associated with influenza vaccination: two adult cases

Intern Med. 2003 Feb;42(2):191-4. doi: 10.2169/internalmedicine.42.191.

Abstract

We describe two adult cases of neurologic complications occurring after influenza vaccination. The first case was a 62-year-old man who experienced convulsions 5 days after vaccination, and the second case was a 70-year-old man who exhibited paraplegia 7 days after vaccination. Diagnoses of acute disseminated encephalomyelitis and transverse myelitis with acute motor axonal neuropathy were made, respectively, and steroid pulse therapy and intravenous gamma globulin therapy alleviated the patients' symptoms. Although the efficacy and cost benefit of influenza vaccination have been widely accepted, such neurologic complications might occur in the elderly or even in adults.

Publication types

  • Case Reports

MeSH terms

  • Age Factors
  • Aged
  • Encephalomyelitis, Acute Disseminated / chemically induced*
  • Encephalomyelitis, Acute Disseminated / drug therapy
  • Encephalomyelitis, Acute Disseminated / pathology
  • Follow-Up Studies
  • Guillain-Barre Syndrome / chemically induced*
  • Guillain-Barre Syndrome / drug therapy
  • Guillain-Barre Syndrome / pathology
  • Humans
  • Immunoglobulins, Intravenous / administration & dosage
  • Influenza Vaccines / administration & dosage
  • Influenza Vaccines / adverse effects*
  • Influenza, Human / prevention & control*
  • Magnetic Resonance Imaging
  • Male
  • Methylprednisolone / administration & dosage
  • Middle Aged
  • Pulse Therapy, Drug
  • Risk Assessment
  • Treatment Outcome
  • Vaccination / adverse effects

Substances

  • Immunoglobulins, Intravenous
  • Influenza Vaccines
  • Methylprednisolone