Potentiation of anti-cancer effect by intravenous administration of vesiculated alpha-tocopheryl hemisuccinate on mouse melanoma in vivo

Cancer Lett. 2003 Mar 20;192(1):19-24. doi: 10.1016/s0304-3835(02)00683-3.


We examined the effect of alpha-tocopheryl hemisuccinate (TS) on the growth of mouse melanoma cells B16-F1 inoculated on the back of hairless mice by two administration procedures of TS, i.p. administration of TS dissolved with dimethyl sulfoxide (TS i.p.) and i.v. administration of TS vesicles (TS-vesicle i.v.). TS i.p. significantly prevented the tumor growth of only half the mice in the group. However, TS-vesicle i.v. almost completely inhibited the tumor growth of all mice. Furthermore, the mean survival of the TS-vesicle i.v. group was 1.4-fold those of the control and TS i.p. groups.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Cell Division / drug effects
  • Injections, Intraperitoneal
  • Injections, Intravenous
  • Male
  • Melanoma / drug therapy*
  • Melanoma / pathology
  • Mice
  • Mice, Hairless
  • Neoplasm Transplantation
  • Survival Rate
  • Time Factors
  • Tocopherols
  • Tumor Cells, Cultured
  • Vitamin E / administration & dosage*
  • Vitamin E / analogs & derivatives*
  • Vitamin E / pharmacology
  • Vitamin E / therapeutic use*


  • Vitamin E
  • Tocopherols