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, 13 (4), 697-700

Orally Efficacious NR2B-selective NMDA Receptor Antagonists

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Orally Efficacious NR2B-selective NMDA Receptor Antagonists

Christopher F Claiborne et al. Bioorg Med Chem Lett.

Abstract

A novel series of benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 31 is orally active in a carrageenan-induced rat hyperalgesia model of pain and shows no motor coordination side effects.

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