HIF hydroxylation and the mammalian oxygen-sensing pathway

J Clin Invest. 2003 Mar;111(6):779-83. doi: 10.1172/JCI18181.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis Regulatory Proteins
  • Asparagine
  • Basic Helix-Loop-Helix Transcription Factors
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Hydroxylation
  • Hypoxia-Inducible Factor 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Ligases / genetics
  • Nuclear Proteins / metabolism*
  • Oxygen / metabolism*
  • Proline
  • Repressor Proteins
  • Trans-Activators / metabolism*
  • Transcription Factors / metabolism*
  • Tumor Suppressor Proteins*
  • Ubiquitin-Protein Ligases*
  • Von Hippel-Lindau Tumor Suppressor Protein
  • von Hippel-Lindau Disease / genetics

Substances

  • Apoptosis Regulatory Proteins
  • Basic Helix-Loop-Helix Transcription Factors
  • DNA-Binding Proteins
  • HIF1A protein, human
  • HIF3A protein, human
  • Hypoxia-Inducible Factor 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Nuclear Proteins
  • Repressor Proteins
  • Trans-Activators
  • Transcription Factors
  • Tumor Suppressor Proteins
  • endothelial PAS domain-containing protein 1
  • Asparagine
  • Proline
  • Ubiquitin-Protein Ligases
  • Von Hippel-Lindau Tumor Suppressor Protein
  • Ligases
  • VHL protein, human
  • Oxygen