Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene

Nature. 1976 Apr 8;260(5551):500-7. doi: 10.1038/260500a0.


Bacteriophage MS2 RNA is 3,569 nucleotides long. The nucleotide sequence has been established for the third and last gene, which codes for the replicase protein. A secondary structure model has also been proposed. Biological properties, such as ribosome binding and codon interactions can now be discussed on a molecular basis. As the sequences for the other regions of this RNA have been published already, the complete, primary chemical structure of a viral genome has now been established.

MeSH terms

  • Base Sequence
  • Codon
  • Coliphages / analysis*
  • Nucleic Acid Conformation
  • Protein Biosynthesis
  • RNA, Viral / analysis*
  • RNA, Viral / metabolism
  • Viral Proteins*


  • Codon
  • RNA, Viral
  • Viral Proteins

Associated data

  • GENBANK/J02467
  • GENBANK/V00642