An introduction to pancreatic adenocarcinoma genetics, pathology and therapy

Cancer Biol Ther. Nov-Dec 2002;1(6):607-13. doi: 10.4161/cbt.307.


Cancer is bad, but pancreatic cancer is especially so. Underlying the aggressive behavior of pancreatic cancer is a highly patterned set of biologic rules for its development. The accumulating discoveries regarding the genetic basis of pancreatic cancer and developments in the clinical management of the disease provide hope for meaningful improvements in the understanding and control of this disease.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma* / genetics
  • Adenocarcinoma* / pathology
  • Adenocarcinoma* / therapy
  • Animals
  • Biomarkers, Tumor / genetics
  • Gene Expression Regulation, Neoplastic / physiology
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Mutation
  • Pancreatic Neoplasms* / genetics
  • Pancreatic Neoplasms* / pathology
  • Pancreatic Neoplasms* / therapy


  • Biomarkers, Tumor