Emerging Paradigms for Understanding Fatness and Diabetes Risk

Curr Diab Rep. 2002 Jun;2(3):223-30. doi: 10.1007/s11892-002-0087-1.


It is widely accepted that increasing adiposity is associated with insulin resistance and increased risk of type 2 diabetes. The predominant paradigm used to explain this link is the portal/visceral hypothesis. This hypothesis proposes that increased adiposity, particularly in the visceral depots, leads to increased free fatty acid flux and inhibition of insulin action via Randle's effect in insulin-sensitive tissues. Recent data do not entirely support this hypothesis. As such, two new paradigms have emerged that may explain the established links between adiposity and disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Diabetes Mellitus / etiology*
  • Humans
  • Models, Biological*
  • Obesity / complications*
  • Risk Factors