S-100 proteins in the human peripheral nervous system

Microsc Res Tech. 2003 Apr 15;60(6):633-8. doi: 10.1002/jemt.10304.


This article reviews the distribution of S100 proteins in the human peripheral nervous system. The expression of S100 by peripheral glial cells seems to be a distinctive fact of these cells, independently of their localization and their ability to myelinate or not. S100 proteins expressing cells include satellite cells of sensory, sympathetic and enteric ganglia, supporting cells of the adrenal medulla, myelinating and non-myelinating Schwann cells in the nerve trunks, and the Schwann-related cells of sensory corpuscles. In addition, S100 proteins are expressed in peripheral neurons. Most of them express S100alpha protein, and a subpopulation of sensory neurons in dorsal root ganglia contains S100beta protein or S100alpha plus S100beta proteins.

Publication types

  • Review

MeSH terms

  • Ganglia / metabolism
  • Humans
  • Immunohistochemistry
  • Neurons / metabolism
  • Peripheral Nervous System / metabolism*
  • Peripheral Nervous System / pathology
  • Peripheral Nervous System Neoplasms / metabolism*
  • Peripheral Nervous System Neoplasms / pathology
  • S100 Proteins / metabolism*
  • Schwann Cells / metabolism


  • S100 Proteins