Abstract
During a large-scale screen of a human fetal brain cDNA library, a full-length cDNA encoding a novel Rap2 interacting protein was isolated and sequenced. The cDNA is 3397bp long and has a predicted open reading frame encoding a protein of 329 aa. The predicted protein shows high homology to mouse and human RPIP8, and has a RUN domain near its C-terminus. The gene was mapped to human chromosome 7q21-7q22 and has 9 exons and 8 introns. The expression pattern was also detected by cycle-limited reverse polymerase chain reaction (RT-PCR).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Carrier Proteins / genetics*
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Carrier Proteins / metabolism*
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Chromosomes, Human, Pair 7*
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Cloning, Molecular
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DNA, Complementary
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Gene Expression
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Humans
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Intracellular Signaling Peptides and Proteins
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Molecular Sequence Data
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Nerve Tissue Proteins / genetics*
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Nerve Tissue Proteins / metabolism*
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Organ Specificity
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Physical Chromosome Mapping
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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rap GTP-Binding Proteins / metabolism*
Substances
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Carrier Proteins
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DNA, Complementary
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Intracellular Signaling Peptides and Proteins
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Nerve Tissue Proteins
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RUNDC3B protein, human
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RAP2A protein, human
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Rap2a protein, mouse
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rap GTP-Binding Proteins