Transient and reversible parkinsonism after acute organophosphate poisoning

J Toxicol Clin Toxicol. 2003;41(1):67-70. doi: 10.1081/clt-120018273.


Parkinsonism is a rare complication in patients with organophosphate poisoning. To date there have been two cases of transient parkinsonism after acute and severe cholinergic crisis, both of which were successfully treated using amantadine, an anti-parkinsonism drug. We report on an 81-year-old woman who was admitted for the treatment of acute severe organophosphate poisoning. Although acute cholinergic crisis was treated successfully with large doses of atropine and 2-pyridine aldoxime methiodide (PAM), extrapyramidal manifestations were noticed on hospital day 6. The neurological symptoms worsened, and the diagnosis of parkinsonism was made by a neurologist on hospital day 9. Immediately, biperiden (5mg), an anti-parkinsonism drug, was administered intravenously, and her symptoms markedly improved. From the following day, biperiden (5 mg/day) was given intramuscularly for eight days. Subsequently, neurological symptoms did not relapse, and no drugs were required. Our patient is the third case of parkinsonism developing after an acute severe cholinergic crisis and the first case successfully treated with biperiden. Patients should be carefully observed for the presence of neurological signs in this kind of poisoning. If present, an anti-parkinsonism drug should be considered.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biperiden / therapeutic use
  • Cholinesterases / blood
  • Dichlorvos / poisoning*
  • Female
  • Humans
  • Insecticides / poisoning*
  • Muscarinic Antagonists / therapeutic use
  • Muscle Rigidity / chemically induced
  • Muscle Rigidity / therapy
  • Parasympathetic Nervous System / physiopathology
  • Parkinson Disease, Secondary / chemically induced*
  • Suicide, Attempted
  • Tremor / chemically induced
  • Tremor / therapy


  • Insecticides
  • Muscarinic Antagonists
  • Biperiden
  • Dichlorvos
  • Cholinesterases