Fragile sites: breaking up over a slowdown

Curr Biol. 2003 Mar 18;13(6):R231-3. doi: 10.1016/s0960-9822(03)00158-1.

Abstract

Common fragile sites are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Recent data suggest that these sites depend on the checkpoint kinase ATR to maintain their stability.

MeSH terms

  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins*
  • Chromosome Fragility*
  • DNA / biosynthesis*
  • DNA / metabolism*
  • DNA Replication*
  • Humans
  • Models, Biological
  • Protein-Serine-Threonine Kinases / metabolism*

Substances

  • Cell Cycle Proteins
  • DNA
  • ATR protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • Protein-Serine-Threonine Kinases