Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction

Biochem Biophys Res Commun. 2003 Mar 28;303(1):247-50. doi: 10.1016/s0006-291x(03)00326-7.


Lectin-like oxidized low-density lipoprotein receptor (LOX-1/OLR1) has been suggested to play a role in the progression of atherogenesis. We analyzed the OLR1 gene and found a single nucleotide polymorphism (SNP), G501C, in patients with ischemic heart disease from a single family, which resulted in the missense mutation of K167N in LOX-1 protein. We compared the group of patients with myocardial infarction (MI) (n=102) with a group of clinically healthy subjects (n=102), and found that the MI group had a significantly high frequency of 501G/C+501C/C (38.2%) compared with the healthy group (17.6%; p<0.002). The odds ratio for the risk of MI associated with the 501G/C+501C/C genotype was 2.89 (95% CI, 1.51-5.53). These findings suggest that OLR1 or a neighboring gene linked with G501C SNP is important for the incidence of MI. Manipulating LOX-1 activity might be a useful therapeutic and preventative approach for coronary artery disease, especially for individuals with the G501C genotype of OLR1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Disease Progression
  • Female
  • Genotype
  • Humans
  • Lipid Metabolism
  • Male
  • Mutation
  • Mutation, Missense
  • Myocardial Infarction / genetics*
  • Odds Ratio
  • Pedigree
  • Polymorphism, Single Nucleotide
  • Polymorphism, Single-Stranded Conformational
  • Receptors, LDL / genetics*
  • Receptors, LDL / metabolism*
  • Receptors, Oxidized LDL
  • Reverse Transcriptase Polymerase Chain Reaction
  • Risk Factors
  • Scavenger Receptors, Class E


  • OLR1 protein, human
  • Receptors, LDL
  • Receptors, Oxidized LDL
  • Scavenger Receptors, Class E