[The comparison of tianeptine and carbamazepine in benzodiazepines withdrawal symptoms]

Psychiatr Pol. 2002 Nov-Dec;36(6 Suppl):311-8.
[Article in Polish]


Dealing with benzodiazepine dependent creates as serious clinical problem that requires knowledge and experience. Abrupt discontinuation of benzodiazepines, particularly those with short half-life is not advised to avoid severe withdrawal syndrome. Reports from literature suggest use of carbamazepine and recently tianeptine as substances useful in treatment of benzodiazepine dependence. This paper presents a double-blind trial in which both, carbamazepine and tianeptine were used in treatment of benzodiazepiene withdrawal syndrome. Patient mental state was evaluated by using questionnaire SCL-90, Beck Depression Inventory and specifically designed questionnaire assessing severity of symptoms following benzodiazepine withdrawal. It appears from this study that both drugs (carbamazepine and tianeptine) are comparable, safe and efficient in treating benzodiazepine withdrawal symptoms.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Anxiety Agents / adverse effects*
  • Anticonvulsants / administration & dosage*
  • Antidepressive Agents, Tricyclic / administration & dosage*
  • Anxiety Disorders / chemically induced*
  • Anxiety Disorders / drug therapy*
  • Anxiety Disorders / psychology
  • Benzodiazepines
  • Carbamazepine / administration & dosage*
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Poland
  • Substance Withdrawal Syndrome / drug therapy*
  • Substance Withdrawal Syndrome / etiology
  • Thiazepines / administration & dosage*
  • Time Factors
  • Treatment Outcome


  • Anti-Anxiety Agents
  • Anticonvulsants
  • Antidepressive Agents, Tricyclic
  • Thiazepines
  • tianeptine
  • Benzodiazepines
  • Carbamazepine